In this article by Patterson et al [Patterson BK, Francisco EB, Yogendra R, et al. Persistence of SARS CoV-2 S1 protein in CD16+ monocytes in post-acute sequelae of COVID-19 (PASC) up to 15 months post-infection. Front Immunol. 2022 Jan 10;12:746021. doi: 10.3389/fimmu.2021.746021.], it might be possible that integration occurred in this individual. Whether it was due to shedding or not remains to be determined.
For patients with IgG spike antibody titres at or above a dilution of 1/25,000 (BTW is this IgG1/3 or IgG2/4? and does it matter?), this might be an indication of integration of the vaccine derived nucleotide sequences into genomic DNA (i.e., the dreaded genetic modification of humans). Instead of trying to biopsy each organ in the body, we could purify genomic DNA from plasma. The contents of recently lysed cells (say the ones expressing the vaccine sequence for spike which are killed by the immune system in the presence of ivermectin and zinc) could be examined for gene copy number for the spike gene and for HERV-K102 [see my real time PCR method used in Laderoute MP et al, Open AIDS Journal, 2015 on how to run the tests for genomic DNA and exclude cDNA of the HERV-K102 particles. If HERV-K102 copy number is elevated (for example in people with high levels of spike antibody and not in those with little or no antibody and there is no active SARS-CoV-2 infection, this might imply that the exosomes associated with shedding might be the 100 nm HERV-K102 particles. In this case, one would like to also examine genomic DNA in macrophages/monocytes and in the bone marrow progenitors of the monocytes/macrophages. It is possible that integration might more commonly occur as a direct consequence of shedding (from HERV-K102 particles produced in sebocytes found in sebaceous glands in the mucosa carrying the RNA or DNA sequence of spike).
Of course shedding to the ever vaccinated from the ever vaccinated also occurred. The problem here is how to determine what pathology related to the direct inoculation of the Pfizer mRNA vaccine versus shedding and of course that due to breakthrough infections.
Dr Pierre Kory uses the levels of spike antibody as a surrogate marker for shedding, such as in discordant couples (one recently vaccinated, the other not, but the latter showing some symptoms). Some of these antibody levels reach extreme levels, making one ponder if there was an integration event in the new host but not in the original shedder ? I hate to say it but, if the vaccine LNPs get targeted to sebocytes in sebaceous glands in the upper respiratory tract (URT) in the vaccinated, the resulting HERV-K102 particles (around 100 nms which is mid-size for exosomes) that undergo reverse transcription and which carry integrase and become integrated, would be released in saliva and in aerosols. Upon absorption in the URT, lungs, skin or other types of mucosa of the new host, this could set up spike continuous manufacturing related to integration. If the cell type is a macrophage/sebocyte, it likely would not express spike (or HERV-K102 envelope) at its cell surface so it would be refractory to elimination. Spike protein then causes clotting/low zeta potential in the circulation (sudden death) and/or induces immunosenescence which favors cardiovascular disease and cancers. So in this hypothetical scenario, integration is more likely upon shedding to new host which fits with the very high levels of spike antibody as sometimes observed by Dr. Kory. To fix the problem, probably need to use a cocktail of alpha-fetoprotein antagonists: IVERMECTIN (or possibly Artemisinin/Artesunate), zinc, isoflavonoids (genistein), ensure vitamin D levels are well over 50 ng/ml, and in the USA could also include 7 keto-DHEA. Raises the issue that integration of spike sequences into genomic DNA may be more common relating to shedding, so the recently vaccinated may not be the population that would be most informative for possible integration. Thoughts?
Evidence that spike antibody isotypes seem to have enhanced the risk of death in the unvaccinated implies a mechanism of death pertained at least to the targeting of foamy macrophages and induction of immunosenescence in the old and new host. It is noteworthy that evidence of transfer of spike specific antibodies via shedding has been shown [ Kedl RM et al, 2023, Immunohorizons].
I wonder about morbidity and mortality spiking among the UK "unvaccinated" at the same time as amongst the "vaccinated".
We do know that in the US a whole lot of "vaccinated" people, admitted to hospitals with COVID, were entered as "unvaccinated", unless they had received a second dose more than 2 weeks prior AND that information was Already entered in the medical records at That Hospital.
I don't know exactly the methodology used to classify "vaccinated" and "unvaccinated" in the UK, but some of that same kind of misclassification bleed-over may have been at play.
In the UK ONS data, the summary Mortality rate data (per 100,000 person-years) provided in the document for the ever vaccinated were fraudulently adjusted down to exclude deaths that occurred within the first 14 days. Prof. Norman Fenton has confronted the ONS on this point and apparently they admitted to adding these deaths to the unvaxed. However, deaths under 21 days after vaccination were in fact recorded and I counted them in my totals for the ever vaxed. To generate the summary rates in the ever vaxed for my analysis, I had to add up (Compile) the individual rates for each dose which provided a much higher number than what the ONS admitted in their summary data. It should be noted that according to Prof Fenton the data would still be unusable. However, the overall rate patterns (and raw death counts including up to the first 21 days) between the vaxed and unvaxed resembles what one would predict. The ONS data examined their own death and causes database (legally required regardless of pandemics) and linked it to the registry for COVID-19 vaccinations (PHE which became UKHSA). Note at the time of mandated reporting of deaths, each physician would make decisions as to cause of death (clarified by autopsy if there was one). The UK had an extraordinary, very high peak of COVID-19 deaths in April 2020 which some have argued they actually died from the drugs (toxic combinations) used in the old age nursing homes (by protocols) and not so much COVID-19. Also after the emergence of OMICRON there was confusion as to cause of death namely the "from COVID-19 vs with COVID-19" dilemma. An examination of the mortality rates for the vaxed or unvaxed shows most deaths in 2022 were captured in the non-C19 category. Yes, the data are not absolutely clean, but one works with what one has. NB: According to Prof. Fenton's arguments, here the data might be overestimating the toxic effects of shedding on mortality in the unvaccinated. However, as best as I can tell, deaths under 21 days post immunization were captured under the ever vaccinated in my analysis meaning the data would not be overestimating the shedding risk to the unvaccinated by this criteria. I hope this helps.
Prof. Steven Pelech in Vancouver is doing some studies on antibodies at Kinexus.
I have difficulty determining who might be SARS-CoV-2 injured and who is Vaxx-injured.
If his lab can quantitate S protein levels vs the other Corona proteins we might be able to determine who was Vaxx-injured vs infective sequelae. The sidestream effects would be more subtle, as we assume at least 90% of the population has been exposed and recovered (unless we are Fisman.)
My wife is reliably sensitive to shedding from recently vaxxed contacts. I had not really considered that people would be eligible to die from this, even appreciating the stoichiometry of an infection vs an injection- apparently 14 x 10^12 more spikes from the shot than the snot. I was aware of reports of foetal demise after pregnant women's mRNA injections, and infant death with breastfeeding of recently injected mothers.
Isolating and sequencing the spike protein would indicate if it came from the vax or from an infection (eg sequences are not the same, and in fact there are two inserted prolines at the trypsin recognition site. Vax spike is trypsin resistant (so you don't even have to sequence). Most likely a death from shedding to an unvaccinated individual is due to integration and non-stop spike protein production. Some say that transfection of E. coli in our gut might contribute to post vax symptoms (ie., in the vaccinated). I am suggesting when the LNP enter sebocytes or the progenitors of sebocytes in the vaccinated person (cells of sebaceous glands in the mucosa in the upper respiratory tract (URT), that the HERV-K102 particles pick up this vaccine DNA and RNA and the latter undergo 1) reverse transcription. These particles get released as aerosols but if the person is vaccinated there may be antibodies to spike protein on the surface of the particles, which then targets the particles preferentially into macrophages/sebocytes in the host's URT. In the new host this causes immunosenescence, clotting, vasculitis, neurodegeneration, CVD, cancers and could result in sudden death if say under 65. You would only need one integration of spike sequence to cause death (one genetic modification of the host).
In this article by Patterson et al [Patterson BK, Francisco EB, Yogendra R, et al. Persistence of SARS CoV-2 S1 protein in CD16+ monocytes in post-acute sequelae of COVID-19 (PASC) up to 15 months post-infection. Front Immunol. 2022 Jan 10;12:746021. doi: 10.3389/fimmu.2021.746021.], it might be possible that integration occurred in this individual. Whether it was due to shedding or not remains to be determined.
For patients with IgG spike antibody titres at or above a dilution of 1/25,000 (BTW is this IgG1/3 or IgG2/4? and does it matter?), this might be an indication of integration of the vaccine derived nucleotide sequences into genomic DNA (i.e., the dreaded genetic modification of humans). Instead of trying to biopsy each organ in the body, we could purify genomic DNA from plasma. The contents of recently lysed cells (say the ones expressing the vaccine sequence for spike which are killed by the immune system in the presence of ivermectin and zinc) could be examined for gene copy number for the spike gene and for HERV-K102 [see my real time PCR method used in Laderoute MP et al, Open AIDS Journal, 2015 on how to run the tests for genomic DNA and exclude cDNA of the HERV-K102 particles. If HERV-K102 copy number is elevated (for example in people with high levels of spike antibody and not in those with little or no antibody and there is no active SARS-CoV-2 infection, this might imply that the exosomes associated with shedding might be the 100 nm HERV-K102 particles. In this case, one would like to also examine genomic DNA in macrophages/monocytes and in the bone marrow progenitors of the monocytes/macrophages. It is possible that integration might more commonly occur as a direct consequence of shedding (from HERV-K102 particles produced in sebocytes found in sebaceous glands in the mucosa carrying the RNA or DNA sequence of spike).
Of course shedding to the ever vaccinated from the ever vaccinated also occurred. The problem here is how to determine what pathology related to the direct inoculation of the Pfizer mRNA vaccine versus shedding and of course that due to breakthrough infections.
Dr Pierre Kory uses the levels of spike antibody as a surrogate marker for shedding, such as in discordant couples (one recently vaccinated, the other not, but the latter showing some symptoms). Some of these antibody levels reach extreme levels, making one ponder if there was an integration event in the new host but not in the original shedder ? I hate to say it but, if the vaccine LNPs get targeted to sebocytes in sebaceous glands in the upper respiratory tract (URT) in the vaccinated, the resulting HERV-K102 particles (around 100 nms which is mid-size for exosomes) that undergo reverse transcription and which carry integrase and become integrated, would be released in saliva and in aerosols. Upon absorption in the URT, lungs, skin or other types of mucosa of the new host, this could set up spike continuous manufacturing related to integration. If the cell type is a macrophage/sebocyte, it likely would not express spike (or HERV-K102 envelope) at its cell surface so it would be refractory to elimination. Spike protein then causes clotting/low zeta potential in the circulation (sudden death) and/or induces immunosenescence which favors cardiovascular disease and cancers. So in this hypothetical scenario, integration is more likely upon shedding to new host which fits with the very high levels of spike antibody as sometimes observed by Dr. Kory. To fix the problem, probably need to use a cocktail of alpha-fetoprotein antagonists: IVERMECTIN (or possibly Artemisinin/Artesunate), zinc, isoflavonoids (genistein), ensure vitamin D levels are well over 50 ng/ml, and in the USA could also include 7 keto-DHEA. Raises the issue that integration of spike sequences into genomic DNA may be more common relating to shedding, so the recently vaccinated may not be the population that would be most informative for possible integration. Thoughts?
Evidence that spike antibody isotypes seem to have enhanced the risk of death in the unvaccinated implies a mechanism of death pertained at least to the targeting of foamy macrophages and induction of immunosenescence in the old and new host. It is noteworthy that evidence of transfer of spike specific antibodies via shedding has been shown [ Kedl RM et al, 2023, Immunohorizons].
I wonder about morbidity and mortality spiking among the UK "unvaccinated" at the same time as amongst the "vaccinated".
We do know that in the US a whole lot of "vaccinated" people, admitted to hospitals with COVID, were entered as "unvaccinated", unless they had received a second dose more than 2 weeks prior AND that information was Already entered in the medical records at That Hospital.
I don't know exactly the methodology used to classify "vaccinated" and "unvaccinated" in the UK, but some of that same kind of misclassification bleed-over may have been at play.
In the UK ONS data, the summary Mortality rate data (per 100,000 person-years) provided in the document for the ever vaccinated were fraudulently adjusted down to exclude deaths that occurred within the first 14 days. Prof. Norman Fenton has confronted the ONS on this point and apparently they admitted to adding these deaths to the unvaxed. However, deaths under 21 days after vaccination were in fact recorded and I counted them in my totals for the ever vaxed. To generate the summary rates in the ever vaxed for my analysis, I had to add up (Compile) the individual rates for each dose which provided a much higher number than what the ONS admitted in their summary data. It should be noted that according to Prof Fenton the data would still be unusable. However, the overall rate patterns (and raw death counts including up to the first 21 days) between the vaxed and unvaxed resembles what one would predict. The ONS data examined their own death and causes database (legally required regardless of pandemics) and linked it to the registry for COVID-19 vaccinations (PHE which became UKHSA). Note at the time of mandated reporting of deaths, each physician would make decisions as to cause of death (clarified by autopsy if there was one). The UK had an extraordinary, very high peak of COVID-19 deaths in April 2020 which some have argued they actually died from the drugs (toxic combinations) used in the old age nursing homes (by protocols) and not so much COVID-19. Also after the emergence of OMICRON there was confusion as to cause of death namely the "from COVID-19 vs with COVID-19" dilemma. An examination of the mortality rates for the vaxed or unvaxed shows most deaths in 2022 were captured in the non-C19 category. Yes, the data are not absolutely clean, but one works with what one has. NB: According to Prof. Fenton's arguments, here the data might be overestimating the toxic effects of shedding on mortality in the unvaccinated. However, as best as I can tell, deaths under 21 days post immunization were captured under the ever vaccinated in my analysis meaning the data would not be overestimating the shedding risk to the unvaccinated by this criteria. I hope this helps.
Thank you for your rigor in this analysis, Dr. Laderoute.
Prof. Steven Pelech in Vancouver is doing some studies on antibodies at Kinexus.
I have difficulty determining who might be SARS-CoV-2 injured and who is Vaxx-injured.
If his lab can quantitate S protein levels vs the other Corona proteins we might be able to determine who was Vaxx-injured vs infective sequelae. The sidestream effects would be more subtle, as we assume at least 90% of the population has been exposed and recovered (unless we are Fisman.)
My wife is reliably sensitive to shedding from recently vaxxed contacts. I had not really considered that people would be eligible to die from this, even appreciating the stoichiometry of an infection vs an injection- apparently 14 x 10^12 more spikes from the shot than the snot. I was aware of reports of foetal demise after pregnant women's mRNA injections, and infant death with breastfeeding of recently injected mothers.
Isolating and sequencing the spike protein would indicate if it came from the vax or from an infection (eg sequences are not the same, and in fact there are two inserted prolines at the trypsin recognition site. Vax spike is trypsin resistant (so you don't even have to sequence). Most likely a death from shedding to an unvaccinated individual is due to integration and non-stop spike protein production. Some say that transfection of E. coli in our gut might contribute to post vax symptoms (ie., in the vaccinated). I am suggesting when the LNP enter sebocytes or the progenitors of sebocytes in the vaccinated person (cells of sebaceous glands in the mucosa in the upper respiratory tract (URT), that the HERV-K102 particles pick up this vaccine DNA and RNA and the latter undergo 1) reverse transcription. These particles get released as aerosols but if the person is vaccinated there may be antibodies to spike protein on the surface of the particles, which then targets the particles preferentially into macrophages/sebocytes in the host's URT. In the new host this causes immunosenescence, clotting, vasculitis, neurodegeneration, CVD, cancers and could result in sudden death if say under 65. You would only need one integration of spike sequence to cause death (one genetic modification of the host).