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Dr. Marian Laderoute's avatar

In this article by Patterson et al [Patterson BK, Francisco EB, Yogendra R, et al. Persistence of SARS CoV-2 S1 protein in CD16+ monocytes in post-acute sequelae of COVID-19 (PASC) up to 15 months post-infection. Front Immunol. 2022 Jan 10;12:746021. doi: 10.3389/fimmu.2021.746021.], it might be possible that integration occurred in this individual. Whether it was due to shedding or not remains to be determined.

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Dr. Marian Laderoute's avatar

For patients with IgG spike antibody titres at or above a dilution of 1/25,000 (BTW is this IgG1/3 or IgG2/4? and does it matter?), this might be an indication of integration of the vaccine derived nucleotide sequences into genomic DNA (i.e., the dreaded genetic modification of humans). Instead of trying to biopsy each organ in the body, we could purify genomic DNA from plasma. The contents of recently lysed cells (say the ones expressing the vaccine sequence for spike which are killed by the immune system in the presence of ivermectin and zinc) could be examined for gene copy number for the spike gene and for HERV-K102 [see my real time PCR method used in Laderoute MP et al, Open AIDS Journal, 2015 on how to run the tests for genomic DNA and exclude cDNA of the HERV-K102 particles. If HERV-K102 copy number is elevated (for example in people with high levels of spike antibody and not in those with little or no antibody and there is no active SARS-CoV-2 infection, this might imply that the exosomes associated with shedding might be the 100 nm HERV-K102 particles. In this case, one would like to also examine genomic DNA in macrophages/monocytes and in the bone marrow progenitors of the monocytes/macrophages. It is possible that integration might more commonly occur as a direct consequence of shedding (from HERV-K102 particles produced in sebocytes found in sebaceous glands in the mucosa carrying the RNA or DNA sequence of spike).

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