Thank You, Dr. Laderoute, for reiterating that Vitamin-D is a currency of immune system economy, which we can readily provide, to keep our immune system functioning as designed. Some people, such as those who have had gallbladders removed, and many with a lot of body fat (into which vitamin-D diffuses) may need to take 10,000 units per day to get a mid-normal range blood level. Most people over 100# will be well served by 5000 units per day.
Checking a blood level after 3 months on a steady dose is a good idea.
Vitamin K2 seems to be synergistic with vitamin-D in many ways. I don't readily find study information on that, though. I personally take both.
If you read between the lines of this article [Barale C, Cavalot F, Frascaroli C, Bonomo K, Morotti A, Guerrasio A, Russo I. Association between High On-Aspirin Platelet Reactivity and Reduced Superoxide Dismutase Activity in Patients Affected by Type 2 Diabetes Mellitus or Primary Hypercholesterolemia. Int J Mol Sci. 2020 Jul 15;21(14):4983. doi: 10.3390/ijms21144983.] the induction of sCD40L by aspirin in familial hypercholesterolemia (FH) and in T2D seems to be blocked by statins. There should be a warning on the low dose aspirin where it currently says "Call 911, then chew 2 tablets (of aspirin 81 mg), if you think you are having a heart attack. Aspirin may help save your life." They need to add, use in patients with FH or T2D who are not on statin therapy may increase platelet activation (elevates sCD40L) which could worsen clotting and thus cardiovascular symptoms.
In a paper by Swank K et al [Persistent circulating SARS-CoV-2 spike is associated with post-acute COVID-19 sequelae, Zoe Swank, Yasmeen Senussi, Galit Alter, David R. Walt
medRxiv 2022.06.14.22276401; doi: https://doi.org/10.1101/2022.06.14.22276401], 65% of PASC had detectable longer term spike in the blood, potentially associated with elevated CXCL8/IL-8 (1 to 10 pg/ml). This suggests that the glucocorticoid resistance related CIRCI and PICS/macrophage immunosenescence issues discussed by Meduri et al, 2020 are likely part of the syndrome and need to be addressed in the treatment plan in addition to digesting spike protein and replacement of the gut microbiome; ie., methylprednisolone plus the AFP antagonists especially ivermectin/artemisinin, zinc and isoflavones (like genistein).
We do not yet know the source of the S1 protein in the CD16+ monocytes of 73 % of PASC patients of ref 27. Nevertheless it could be the transfection of bacteria in the gut by the mRNA gene therapy vaccines (either having been injected directly or possibly via shedding from the vaccinated). Following the 1st Pfizer mRNA vaccination I slowly developed over 6 weeks, a blocked colon that became life-threatening, and via the dosing with pre and pro-biotics, I was able to recover my normal bowel movements by around 3 months. So if the bacteria in the gut are the source of S1 spike, it might be very useful to replace the contaminated flora with uninfected bacteria. I did not experience this with the second dose possibly because I continued to take the pre and pro biotics (even to present day).
Thank You, Dr. Laderoute, for reiterating that Vitamin-D is a currency of immune system economy, which we can readily provide, to keep our immune system functioning as designed. Some people, such as those who have had gallbladders removed, and many with a lot of body fat (into which vitamin-D diffuses) may need to take 10,000 units per day to get a mid-normal range blood level. Most people over 100# will be well served by 5000 units per day.
Checking a blood level after 3 months on a steady dose is a good idea.
Vitamin K2 seems to be synergistic with vitamin-D in many ways. I don't readily find study information on that, though. I personally take both.
If you read between the lines of this article [Barale C, Cavalot F, Frascaroli C, Bonomo K, Morotti A, Guerrasio A, Russo I. Association between High On-Aspirin Platelet Reactivity and Reduced Superoxide Dismutase Activity in Patients Affected by Type 2 Diabetes Mellitus or Primary Hypercholesterolemia. Int J Mol Sci. 2020 Jul 15;21(14):4983. doi: 10.3390/ijms21144983.] the induction of sCD40L by aspirin in familial hypercholesterolemia (FH) and in T2D seems to be blocked by statins. There should be a warning on the low dose aspirin where it currently says "Call 911, then chew 2 tablets (of aspirin 81 mg), if you think you are having a heart attack. Aspirin may help save your life." They need to add, use in patients with FH or T2D who are not on statin therapy may increase platelet activation (elevates sCD40L) which could worsen clotting and thus cardiovascular symptoms.
In a paper by Swank K et al [Persistent circulating SARS-CoV-2 spike is associated with post-acute COVID-19 sequelae, Zoe Swank, Yasmeen Senussi, Galit Alter, David R. Walt
medRxiv 2022.06.14.22276401; doi: https://doi.org/10.1101/2022.06.14.22276401], 65% of PASC had detectable longer term spike in the blood, potentially associated with elevated CXCL8/IL-8 (1 to 10 pg/ml). This suggests that the glucocorticoid resistance related CIRCI and PICS/macrophage immunosenescence issues discussed by Meduri et al, 2020 are likely part of the syndrome and need to be addressed in the treatment plan in addition to digesting spike protein and replacement of the gut microbiome; ie., methylprednisolone plus the AFP antagonists especially ivermectin/artemisinin, zinc and isoflavones (like genistein).
We do not yet know the source of the S1 protein in the CD16+ monocytes of 73 % of PASC patients of ref 27. Nevertheless it could be the transfection of bacteria in the gut by the mRNA gene therapy vaccines (either having been injected directly or possibly via shedding from the vaccinated). Following the 1st Pfizer mRNA vaccination I slowly developed over 6 weeks, a blocked colon that became life-threatening, and via the dosing with pre and pro-biotics, I was able to recover my normal bowel movements by around 3 months. So if the bacteria in the gut are the source of S1 spike, it might be very useful to replace the contaminated flora with uninfected bacteria. I did not experience this with the second dose possibly because I continued to take the pre and pro biotics (even to present day).