Thankyou Marian, this is an excellent presentation. Are the slides from a formal presentation you have done somewhere? For those of us who do not have biology background and want to understand more it would be great to see this expanded upon.
They are from a formal presentation written as expert testimony for the National Citizens Inquiry (Canadian COVID-19 response). I have now attached the main file in the article. This pdf of the ppt can be downloaded.
A devastating documentation of how the medical establishment can murder people through:
1. Lack of proper treatment of Covid19 using cheap, off-patent methodologies.
2. Lack of any proper clinical trials for Covid19 'vaccines'.
3. Choosing to make antibodies against a SARS-CoV2 protein which is not the primary immune target in natural infections.
4. Refusal to change course when data clearly shows medical outcomes.
The data presented here should constitute a prima faciae case against the entire senior Medical Establishment of the UK, all of whom should lose all their worldly goods and none of whom should retain the right to practice medicine.
However, the conspiracy stretches much further and much wider than the medical profession. It encompasses the entire community of SAGE committee disciplines (notably the brainwashers like Susan Michie). It includes the entirety of the MSM, over 95% of MPs in the House of Commons, 100% of senior civil servants, 100% of senior management of the entire pharmaceutical industry, vast swathes of biomedical academia and the entirety of the malignant and genocidal Security Services.
Thanks for a great explanation of these processes. My Mum is in an aged care facility in Australia,and quite a few of the residents have succumbed to Covid death over the last two years. In fact,it is just re-branded flu in my opinion. But I got my mother taking just 1000IU of vitamin D3 each day,and she hasn't even had a sniffle. Even though she was given 2 doses of AZ early on. Regular sun exposure has also helped,I am sure.
High elevation direct sunshine on unprotected skin converts 7-dehydrocholesterol into vitamin D3. However, this is not available in winter in most of Australia and this ca. 297 nanometre wavelength ultraviolet-B radiation always damages DNA and so increases the risk of skin cancer. Furthermore, the ability to produce vitamin D3 in the skin declines with age.
So UV-B skin exposure cannot safely be relied upon to produce all or most of the vitamin D3 we need for the liver to convert into the 50 ng/mL 125 nmol/L circulating vitamin D3 the immune system needs to function properly.
Without any vitamin D3 supplementation, most people have only 5 to 25 ng/mL circulating 25-hydroxyvitamin D.
Attaining at least 50 ng/mL 125 nmol/L circulating 25-hydroxyvitamin D was and remains the most important and urgently needed action needed to reduce transmission and severity of COVID-19.
With levels lower than this the immune system's innate and adaptive responses become progressively weaker and the risk of wildly dysregulated, indiscriminate cell destroying, inflammatory responses increase.
For 70 kg 154 lb bodyweight without obesity, 0.125 mg (5000 IU) vitamin D3 a day, on average (up to 10 days between intakes is OK) will raise circulating 25-hydroxyvitamin D to at least 50 ng/mL over several months.
For more on vitamin D3 supplementary intakes as ratios of body weight, with higher ratios for those suffering from obesity, please see: https://vitamindstopscovid.info/00-evi/#sjw-updated-ratios which summarises the recommendations of Emeritus Professor of Medicine Sunil Wimalawansa's article in Nutrients: Rapidly Increasing Serum 25(OH)D Boosts the Immune System, against Infections - Sepsis and COVID-19 https://www.mdpi.com/2072-6643/14/14/2997 .
Apr 30, 2023·edited Apr 30, 2023Liked by Dr. Marian Laderoute
Hello Dr Laderoute, Thanks for your appreciation. You are only the second immunologiist I know of who takes a serious interest in vitamin D. The other is Behdad Afzai MD at NIH: https://www.niddk.nih.gov/about-niddk/staff-directory/biography/afzali-ben who, with Majid Kazemian (who may also be an immunologist) were lead authors of the most important mechanistic article on SARS-CoV-2 triggering severe COVID-19, which involves inflammation in the lungs and consequently hyper-coagulative blood which causes micro-embolisms and larger clots all over the body:
Autocrine vitamin D signaling switches off pro-inflammatory programs of Th1 cells
They elucidated for the first time, 25-hydroxyvitamin D based intracrine (it is a common mistake to think of this as "autocrine") signaling in Th1 regulatory lymphocytes.
Autocrine signalling refers to an intracellularly generated signaling molecule affecting the same cell when it leaves the cell and binds to receptors on the exterior of the cell's plasma membrane. However, this arrangement is not currently known to exist with 1,25-dihydroxvitamin D.
This dense cell-biology article describes the Th1 cells from the lungs of hospitalised COVID-19 patients being unable to transition from their pro-inflammatory startup program to their anti-inflammatory shutdown program, despite detecting the signal to do so (a high level of a complement protein) and despite this detection activating the 25-hydroxyvitamin D based intracrine signaling system by creating VDR and the 1-hydroxylase enzyme in the cell's cytosol. The primary or sole reason for this failure is lack of 25-hydroxyvitamin D
When the system works properly, intracellular 25-hydroxyvitamin D is hydroxylated to 1,25-dihydroxyvitamin D calcitriol which activates the VDR ("vitamin D" - really "calcitriol" receptor) molecules which then migrate to the nucleus and change cell behavior by up- and down-regulating the transcription of dozens to hundreds of genes.
There being no accessible, tutorial-style, peer-reviewed, explanation of 25-hydroxyvitamin D based intracrine and paracrine signaling, my submission to a UK government inquiry (co-signed by Patrick Chambers MD) begins with such a tutorial: https://vitamindstopscovid.info/00-evi/.
Immunologists are busy with all sorts of intrigues such as regarding this epitope, that antibody, the other cytokine and numerous SNPs. In general it seems they don't think about the vitamin D compounds from one year to the next. "Vitamin D" does not appear in the indices of two recent highly regarded immunology textbooks: Janeways 9th and Abbas' 10th editions. The only mention of intracrine signaling I could find in these was for some other compound.
You and anyone else with a strong interest in reading and discussing research into nutrition and the immune system are especially welcome to join the Nutrition for Immune System Health (NISH) email discussion list, whose members include leading vitamin D researchers with decades of experience: https://nish.groups.io . This includes those with no formal qualifications - I have none.
I worked as Lab & Research Director at Immune System Management Clinic & Lab in Ottawa, Ontario Canada where we provided nutritional approaches to the reversion of immunosenescence (dysfunctional foamy macrophages) which causes various chronic diseases such as cancer, cardiovascular disease and type 2 diabetes to mention a few. This group has been reversing and preventing immunosenescence since 1998. I will certainly have a look at the NISH discussion group. Once again thank you so much for your useful comments and information!
I just listened to another expert witness and she said COVID attachs were significantly less in warmer weather the winter months are the worst! I live across from an old people’s home November to March are the worst months!
I know Alberta acknowledges that cause of death unknown is the number one cause of death! Why because if the doctor acknowledges adverse reaction to the vaccine as the cause of feath he or she will lose his or license to practice medacine! In the states doctors are told to encourage friends and families to cremate or whatever they do don’t get an autopsy?! Autopsy identifies case of death and the government doesn’t want people to know!
Over all death rate since COVID is up 40-60% according to insurance companies actuaries! Particularly disturbing is it is young healthy people!
I am beginning to hear some insurance companies are going bankrupt due these extra claims!
I wonder if the nasal epithelium-derived extracellular vesicles (EVs) described in this paper are the same as your HERV-K102 foamy retrovirus particles:
They note that exposure to cold temporarily lowers production of these things, possibly explaining why we are more vulnerable to respiratory infections in winter.
Thankyou Marian, this is an excellent presentation. Are the slides from a formal presentation you have done somewhere? For those of us who do not have biology background and want to understand more it would be great to see this expanded upon.
They are from a formal presentation written as expert testimony for the National Citizens Inquiry (Canadian COVID-19 response). I have now attached the main file in the article. This pdf of the ppt can be downloaded.
Thank you for this fine work, Dr.Laderoute. It is both tecnically well supported and accessible to the layperson.
Thank you.
A devastating documentation of how the medical establishment can murder people through:
1. Lack of proper treatment of Covid19 using cheap, off-patent methodologies.
2. Lack of any proper clinical trials for Covid19 'vaccines'.
3. Choosing to make antibodies against a SARS-CoV2 protein which is not the primary immune target in natural infections.
4. Refusal to change course when data clearly shows medical outcomes.
The data presented here should constitute a prima faciae case against the entire senior Medical Establishment of the UK, all of whom should lose all their worldly goods and none of whom should retain the right to practice medicine.
However, the conspiracy stretches much further and much wider than the medical profession. It encompasses the entire community of SAGE committee disciplines (notably the brainwashers like Susan Michie). It includes the entirety of the MSM, over 95% of MPs in the House of Commons, 100% of senior civil servants, 100% of senior management of the entire pharmaceutical industry, vast swathes of biomedical academia and the entirety of the malignant and genocidal Security Services.
Thanks for a great explanation of these processes. My Mum is in an aged care facility in Australia,and quite a few of the residents have succumbed to Covid death over the last two years. In fact,it is just re-branded flu in my opinion. But I got my mother taking just 1000IU of vitamin D3 each day,and she hasn't even had a sniffle. Even though she was given 2 doses of AZ early on. Regular sun exposure has also helped,I am sure.
High elevation direct sunshine on unprotected skin converts 7-dehydrocholesterol into vitamin D3. However, this is not available in winter in most of Australia and this ca. 297 nanometre wavelength ultraviolet-B radiation always damages DNA and so increases the risk of skin cancer. Furthermore, the ability to produce vitamin D3 in the skin declines with age.
So UV-B skin exposure cannot safely be relied upon to produce all or most of the vitamin D3 we need for the liver to convert into the 50 ng/mL 125 nmol/L circulating vitamin D3 the immune system needs to function properly.
Without any vitamin D3 supplementation, most people have only 5 to 25 ng/mL circulating 25-hydroxyvitamin D.
Attaining at least 50 ng/mL 125 nmol/L circulating 25-hydroxyvitamin D was and remains the most important and urgently needed action needed to reduce transmission and severity of COVID-19.
Please see the research articles cited and discussed at: https://vitamindstopscovid.info/00-evi/ .
With levels lower than this the immune system's innate and adaptive responses become progressively weaker and the risk of wildly dysregulated, indiscriminate cell destroying, inflammatory responses increase.
For 70 kg 154 lb bodyweight without obesity, 0.125 mg (5000 IU) vitamin D3 a day, on average (up to 10 days between intakes is OK) will raise circulating 25-hydroxyvitamin D to at least 50 ng/mL over several months.
For more on vitamin D3 supplementary intakes as ratios of body weight, with higher ratios for those suffering from obesity, please see: https://vitamindstopscovid.info/00-evi/#sjw-updated-ratios which summarises the recommendations of Emeritus Professor of Medicine Sunil Wimalawansa's article in Nutrients: Rapidly Increasing Serum 25(OH)D Boosts the Immune System, against Infections - Sepsis and COVID-19 https://www.mdpi.com/2072-6643/14/14/2997 .
Thank you so much for this important information on my favorite vitamin.
Hello Dr Laderoute, Thanks for your appreciation. You are only the second immunologiist I know of who takes a serious interest in vitamin D. The other is Behdad Afzai MD at NIH: https://www.niddk.nih.gov/about-niddk/staff-directory/biography/afzali-ben who, with Majid Kazemian (who may also be an immunologist) were lead authors of the most important mechanistic article on SARS-CoV-2 triggering severe COVID-19, which involves inflammation in the lungs and consequently hyper-coagulative blood which causes micro-embolisms and larger clots all over the body:
Autocrine vitamin D signaling switches off pro-inflammatory programs of Th1 cells
Chauss et al. 2021: https://www.nature.com/articles/s41590-021-01080-3
They elucidated for the first time, 25-hydroxyvitamin D based intracrine (it is a common mistake to think of this as "autocrine") signaling in Th1 regulatory lymphocytes.
Autocrine signalling refers to an intracellularly generated signaling molecule affecting the same cell when it leaves the cell and binds to receptors on the exterior of the cell's plasma membrane. However, this arrangement is not currently known to exist with 1,25-dihydroxvitamin D.
This dense cell-biology article describes the Th1 cells from the lungs of hospitalised COVID-19 patients being unable to transition from their pro-inflammatory startup program to their anti-inflammatory shutdown program, despite detecting the signal to do so (a high level of a complement protein) and despite this detection activating the 25-hydroxyvitamin D based intracrine signaling system by creating VDR and the 1-hydroxylase enzyme in the cell's cytosol. The primary or sole reason for this failure is lack of 25-hydroxyvitamin D
When the system works properly, intracellular 25-hydroxyvitamin D is hydroxylated to 1,25-dihydroxyvitamin D calcitriol which activates the VDR ("vitamin D" - really "calcitriol" receptor) molecules which then migrate to the nucleus and change cell behavior by up- and down-regulating the transcription of dozens to hundreds of genes.
There being no accessible, tutorial-style, peer-reviewed, explanation of 25-hydroxyvitamin D based intracrine and paracrine signaling, my submission to a UK government inquiry (co-signed by Patrick Chambers MD) begins with such a tutorial: https://vitamindstopscovid.info/00-evi/.
Immunologists are busy with all sorts of intrigues such as regarding this epitope, that antibody, the other cytokine and numerous SNPs. In general it seems they don't think about the vitamin D compounds from one year to the next. "Vitamin D" does not appear in the indices of two recent highly regarded immunology textbooks: Janeways 9th and Abbas' 10th editions. The only mention of intracrine signaling I could find in these was for some other compound.
You and anyone else with a strong interest in reading and discussing research into nutrition and the immune system are especially welcome to join the Nutrition for Immune System Health (NISH) email discussion list, whose members include leading vitamin D researchers with decades of experience: https://nish.groups.io . This includes those with no formal qualifications - I have none.
I worked as Lab & Research Director at Immune System Management Clinic & Lab in Ottawa, Ontario Canada where we provided nutritional approaches to the reversion of immunosenescence (dysfunctional foamy macrophages) which causes various chronic diseases such as cancer, cardiovascular disease and type 2 diabetes to mention a few. This group has been reversing and preventing immunosenescence since 1998. I will certainly have a look at the NISH discussion group. Once again thank you so much for your useful comments and information!
Fabulous article. So succinct and chock full of evidence. The future for many is looking grim.
I just listened to another expert witness and she said COVID attachs were significantly less in warmer weather the winter months are the worst! I live across from an old people’s home November to March are the worst months!
I know Alberta acknowledges that cause of death unknown is the number one cause of death! Why because if the doctor acknowledges adverse reaction to the vaccine as the cause of feath he or she will lose his or license to practice medacine! In the states doctors are told to encourage friends and families to cremate or whatever they do don’t get an autopsy?! Autopsy identifies case of death and the government doesn’t want people to know!
Over all death rate since COVID is up 40-60% according to insurance companies actuaries! Particularly disturbing is it is young healthy people!
I am beginning to hear some insurance companies are going bankrupt due these extra claims!
I wonder if the nasal epithelium-derived extracellular vesicles (EVs) described in this paper are the same as your HERV-K102 foamy retrovirus particles:
https://www.jacionline.org/article/S0091-6749(22)01423-3/fulltext#%20
They note that exposure to cold temporarily lowers production of these things, possibly explaining why we are more vulnerable to respiratory infections in winter.