Ivermectin May Help Prevent SARS-CoV-2 Conversion of M1 LB- Foamy Macrophages (Protector) to M2 LB+ Foamy Macrophages (Non-protector) by Preventing MAPK8/Jnk1 Phosphorylation
It should be noted that high viral loads in the nasopharyngeal swabs (NPS) correlated with the presence of SARS-CoV-2 spike protein specific Abs/NAbs in serum while low viral loads were correlated with the absence of antibody (Liu W et al. Emerging Infectious Diseases, 2021). This showed ADE likely played a role in infection.
In Figure 5 f and g of the Huang N et al Nature Medicine, May 2021 paper they demonstrate SARS-CoV-2 protein and mRNA in sebocytes isolated from saliva of a mild COVID-19 patient (see image showing this in a previous blog on how SARS-CoV-2 targets HERV-K102). First, there should NOT be any intact sebocytes in saliva from normal healthy adults as they all lyse prior to being exuded from the glands as sebum. Huang et al did not address this but the lack of intact sebocytes being isolated from normal healthy adults in saliva and used as a negative control probably reflects there weren't any. The patient probably had suboptimal neutralizing antibodies due to vaccination or a previous moderate to severe infection which mediated ADE for entry into sebocytes. Presumably natural immunity including T cell responses and antibodies to other proteins kept the infection mild. The failure of sebocytes to lyse upon SARS-CoV-2 infection substantiates the notion that SARS-CoV-2 infection prevents apoptosis a key feature of immunosenescence.
One dose of the mRNA vaccines (which induces innate immunity) in the USA was associated with the lowest viral loads in NPS stratified by vaccination status in May 2021 (for 2 of 3 SC2 targets) before the emergence of the delta variant. After delta became dominant by July 2021, there was no difference in NPS viral loads by vaccination status and where all showed higher viral loads than in May (Griffin JB et al., MMWR, 70: 1170-1176, 2021). Two things may be happening here. For the 2 dose vaccinated ADE may be promoting infection of sebocytes in May 2021 whereas innate immunity provided some protection. The delta variant might have less affinity for the ACE2 entry receptor and higher affinity for BSG, meaning this variant could equally enter the sebocytes regardless of the presence or not of suboptimal neutralizing antibodies.
The Ren et al Cell, 2021 study was conducted before the emergence of delta. So it could mean that with the delta variant, more macrophages in BALF actually used BSG to enter cells in addition to enhancement through CD32 (FCGR2a) which by the way gets upregulated with monocyte to macrophage differentiation. So it will be important to see if the issue of phosphorylation of MAPK8/JNK1 persists when BSG is preferentially used to enter macrophages. Note this helps to also explain the controversy as to whether BSG is used for SARS-CoV-2 entry in the absence of ADE. However, it does complicate the question of how ivermectin prevents COVID-19 severity.
A very interesting gentleman, affected by the war ww2.
The great backpeddle is starting along with the great retrenching and refortifying. Luckily for the planet there are honourable scientist doctor researchers in the world. people that stood against the corporate profiteers. We are greatful.
As we know now the corporate machine of distraction is spinning up and I think working well.
We must not be distracted with all the superfluous studies the if / ands /or whats.
Does Ivermectin work, does Hydroxy work, were there protocols available to treat. When were the WHO/CDC/FDA made aware.
If the answer is yes. If those treatments/ prophylaxis were suppressed then murder has been committed. Nothing else matters right now. We must prove our case. Period.
Who committed those murders
Who participated in the great lie, news media of course, doctors, legislators etc…
How do we make people accountable, there is a way that won’t destroy society. I will offer my suggestion in another posting.
I asked that bomber pilot about flak, he said it was somewhat effective. A plane would fly into a cloud of flak which led to the occasional mission failure. The most common thing flak did was to distract and force the plane of course.
Lets not let the flak distract or force us off course.
Is Ivermectin effective, does Hydroxy work, where treatment options available, when did they know.
It should be noted that high viral loads in the nasopharyngeal swabs (NPS) correlated with the presence of SARS-CoV-2 spike protein specific Abs/NAbs in serum while low viral loads were correlated with the absence of antibody (Liu W et al. Emerging Infectious Diseases, 2021). This showed ADE likely played a role in infection.
In Figure 5 f and g of the Huang N et al Nature Medicine, May 2021 paper they demonstrate SARS-CoV-2 protein and mRNA in sebocytes isolated from saliva of a mild COVID-19 patient (see image showing this in a previous blog on how SARS-CoV-2 targets HERV-K102). First, there should NOT be any intact sebocytes in saliva from normal healthy adults as they all lyse prior to being exuded from the glands as sebum. Huang et al did not address this but the lack of intact sebocytes being isolated from normal healthy adults in saliva and used as a negative control probably reflects there weren't any. The patient probably had suboptimal neutralizing antibodies due to vaccination or a previous moderate to severe infection which mediated ADE for entry into sebocytes. Presumably natural immunity including T cell responses and antibodies to other proteins kept the infection mild. The failure of sebocytes to lyse upon SARS-CoV-2 infection substantiates the notion that SARS-CoV-2 infection prevents apoptosis a key feature of immunosenescence.
One dose of the mRNA vaccines (which induces innate immunity) in the USA was associated with the lowest viral loads in NPS stratified by vaccination status in May 2021 (for 2 of 3 SC2 targets) before the emergence of the delta variant. After delta became dominant by July 2021, there was no difference in NPS viral loads by vaccination status and where all showed higher viral loads than in May (Griffin JB et al., MMWR, 70: 1170-1176, 2021). Two things may be happening here. For the 2 dose vaccinated ADE may be promoting infection of sebocytes in May 2021 whereas innate immunity provided some protection. The delta variant might have less affinity for the ACE2 entry receptor and higher affinity for BSG, meaning this variant could equally enter the sebocytes regardless of the presence or not of suboptimal neutralizing antibodies.
The Ren et al Cell, 2021 study was conducted before the emergence of delta. So it could mean that with the delta variant, more macrophages in BALF actually used BSG to enter cells in addition to enhancement through CD32 (FCGR2a) which by the way gets upregulated with monocyte to macrophage differentiation. So it will be important to see if the issue of phosphorylation of MAPK8/JNK1 persists when BSG is preferentially used to enter macrophages. Note this helps to also explain the controversy as to whether BSG is used for SARS-CoV-2 entry in the absence of ADE. However, it does complicate the question of how ivermectin prevents COVID-19 severity.
World
I talked to a bomber pilot a couple of years ago
shawn
21 min ago
A very interesting gentleman, affected by the war ww2.
The great backpeddle is starting along with the great retrenching and refortifying. Luckily for the planet there are honourable scientist doctor researchers in the world. people that stood against the corporate profiteers. We are greatful.
As we know now the corporate machine of distraction is spinning up and I think working well.
We must not be distracted with all the superfluous studies the if / ands /or whats.
Does Ivermectin work, does Hydroxy work, were there protocols available to treat. When were the WHO/CDC/FDA made aware.
If the answer is yes. If those treatments/ prophylaxis were suppressed then murder has been committed. Nothing else matters right now. We must prove our case. Period.
Who committed those murders
Who participated in the great lie, news media of course, doctors, legislators etc…
How do we make people accountable, there is a way that won’t destroy society. I will offer my suggestion in another posting.
I asked that bomber pilot about flak, he said it was somewhat effective. A plane would fly into a cloud of flak which led to the occasional mission failure. The most common thing flak did was to distract and force the plane of course.
Lets not let the flak distract or force us off course.
Is Ivermectin effective, does Hydroxy work, where treatment options available, when did they know.
Shawn663