Attaining at least 50 ng/mL 125 nmol/L circulating 25-hydroxyvitamin D was and remains the most important and urgently needed action needed to reduce transmission and severity of COVID-19.
With levels lower than this the immune system's innate and adaptive responses become progressively weaker and the risk of wildly dysregulated, indiscriminate cell destroying, inflammatory responses increase.
Without proper vitamin D3 supplementation, or recent high levels of ultraviolet B radiation on unprotected, white, skin, most people have only 5 to 25 ng/mL circulating 25-hydroxyvitmain D. Neither vitamin D3 nor 25-hydroxyvitamin D (produced primarily in the liver, over a week or so, from vitamin D3) are hormones.
The kidneys can work fine (producing a very low level of circulating 1,25-dihydroxyvitamin D, which acts as a hormone, by which the kidneys and parathyroid gland regulate calcium-phosphate-bone metabolism) with 20 ng/mL 50 nmol/L, but immune cells need 50 ng/mL 125 nmol/L at least. The immune system is not affected by the very low, stable, level of hormonal 1,25-dihydroxyvitamin D. The immune system does not use hormonal signaling.
It is frequently stated that "vitamin D is a hormone", but this is incorrect. "Vitamin D" is a general term to refer to vitamin D3 cholecalciferol, 25-hydroxyvitamin D calcifediol (or "calcidiol") and 1,25-dihydroxyvitamin D - but they are three separate compounds with different roles.
For 70 kg 154 lb bodyweight without obesity, 0.125 mg (5000 IU) vitamin D3 a day, on average (up to 10 days between intakes is OK) will raise circulating 25-hydroxyvitamin D to at least 50 ng/mL over several months. Bolus (high, single dose) vitamin D3 (for 70 kg BW) such as 10 mg (400,000 IU) raises the level over 4 days or so, due to the delays in hydroxylation in the liver.
The most important and urgently needed treatment for all those who are infected with SARS-CoV-2 and whose 25-hydroxyvitamin D level is well below 50 ng/mL (most people, unless they have been supplementing vitamin D3 properly for a few months) is a single oral dose of calcifediol, which *is* 25-hydroxyvitamin D. This is more reliably absorbed than vitamin D3 (having two hydrophilic hydroxyl groups rather than one) and goes straight into circulation, raising the level safely over 50 ng/mL in 4 hours. 0.014 mg per kg bodyweight is sufficient. For 70 kg this is one milligram of calcifediol. https://nutritionmatters.substack.com/p/calcifediol-to-boost-25-hydroxyvitamin
The same is true for sepsis patients or anyone suffering a clinical emergency and so requiring proper immune system function as a matter of life and death.
Thank you so MUCH for reminding us that the absorption of calcifediol is much better than vitamin D3. The literature substantiates optimal Vitamin D levels as a panacea for many illnesses, and many people during the height of the pandemic should have been informed at the beginning to reduce their COVID-19 risks.
Fauci is a Slytherin, and he himself once mentioned, when asked, that he took 6000 IU per day of vitamin-D, a perfectly reasonable dose. I suspect he checked levels, because it is not an off-the-shelf dose.
Fabulous! I hope Dr Malone and others see this and post on their media. I'm SO thankful to have learned and you confirm the protection of Vitamin D. I used WalkinLab and got my levels checked, no need for a Dr order. My friends say their Drs tell them above 30 is fine, it's so frustrating.
Attaining at least 50 ng/mL 125 nmol/L circulating 25-hydroxyvitamin D was and remains the most important and urgently needed action needed to reduce transmission and severity of COVID-19.
Please see the research articles cited and discussed at: https://vitamindstopscovid.info/00-evi/ .
With levels lower than this the immune system's innate and adaptive responses become progressively weaker and the risk of wildly dysregulated, indiscriminate cell destroying, inflammatory responses increase.
Without proper vitamin D3 supplementation, or recent high levels of ultraviolet B radiation on unprotected, white, skin, most people have only 5 to 25 ng/mL circulating 25-hydroxyvitmain D. Neither vitamin D3 nor 25-hydroxyvitamin D (produced primarily in the liver, over a week or so, from vitamin D3) are hormones.
The kidneys can work fine (producing a very low level of circulating 1,25-dihydroxyvitamin D, which acts as a hormone, by which the kidneys and parathyroid gland regulate calcium-phosphate-bone metabolism) with 20 ng/mL 50 nmol/L, but immune cells need 50 ng/mL 125 nmol/L at least. The immune system is not affected by the very low, stable, level of hormonal 1,25-dihydroxyvitamin D. The immune system does not use hormonal signaling.
It is frequently stated that "vitamin D is a hormone", but this is incorrect. "Vitamin D" is a general term to refer to vitamin D3 cholecalciferol, 25-hydroxyvitamin D calcifediol (or "calcidiol") and 1,25-dihydroxyvitamin D - but they are three separate compounds with different roles.
For 70 kg 154 lb bodyweight without obesity, 0.125 mg (5000 IU) vitamin D3 a day, on average (up to 10 days between intakes is OK) will raise circulating 25-hydroxyvitamin D to at least 50 ng/mL over several months. Bolus (high, single dose) vitamin D3 (for 70 kg BW) such as 10 mg (400,000 IU) raises the level over 4 days or so, due to the delays in hydroxylation in the liver.
The most important and urgently needed treatment for all those who are infected with SARS-CoV-2 and whose 25-hydroxyvitamin D level is well below 50 ng/mL (most people, unless they have been supplementing vitamin D3 properly for a few months) is a single oral dose of calcifediol, which *is* 25-hydroxyvitamin D. This is more reliably absorbed than vitamin D3 (having two hydrophilic hydroxyl groups rather than one) and goes straight into circulation, raising the level safely over 50 ng/mL in 4 hours. 0.014 mg per kg bodyweight is sufficient. For 70 kg this is one milligram of calcifediol. https://nutritionmatters.substack.com/p/calcifediol-to-boost-25-hydroxyvitamin
The same is true for sepsis patients or anyone suffering a clinical emergency and so requiring proper immune system function as a matter of life and death.
If everyone had 50 ng/mL or more circulating 25-hydroxyvitamin D, there would be almost no sepsis, which killed 11 million people, worldwide, in 2017: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(19)32989-7.
Thank you so MUCH for reminding us that the absorption of calcifediol is much better than vitamin D3. The literature substantiates optimal Vitamin D levels as a panacea for many illnesses, and many people during the height of the pandemic should have been informed at the beginning to reduce their COVID-19 risks.
Fauci is a Slytherin, and he himself once mentioned, when asked, that he took 6000 IU per day of vitamin-D, a perfectly reasonable dose. I suspect he checked levels, because it is not an off-the-shelf dose.
Fabulous! I hope Dr Malone and others see this and post on their media. I'm SO thankful to have learned and you confirm the protection of Vitamin D. I used WalkinLab and got my levels checked, no need for a Dr order. My friends say their Drs tell them above 30 is fine, it's so frustrating.
Seminal work and of great importance
Thank you so much John.
Thank you Marian.