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Dr. Marian Laderoute's avatar

I would also like to warn about the use of hypericum (St. John's wort). While hypericum blocks insomnia, fatigue and brain fog, it seems to do this via inhibiting HERV-K102 particle production in vivo [Laderoute MP. Clues to finding correlates of risk/protection for HIV-1 vaccines [version 2; peer review: 2 approved with reservations] F1000Research 2018, 6:868 https://doi.org/10.12688/f1000research.11818.2. ]. That is to say that I was on hypericum for my chronic fatigue syndrome (zero HERV-K102 particles per ml of plasma) and upon dechallenge (stopped the therapy) at 84 hours I had 2.55 x 10 (11) particles per ml of plasma (proven to be cDNA and not genomic DNA). Hypericum also blocks HERV-K102 particle production in vitro (unpublished data). While Z-DTOX [zstacklife.com] does not contain anything that blocks HERV-K102 particle production, the so called Z-SHIELD contains both St. John's wort and turmeric which block HERV-K102 particle production. I think Dr. Mary Bowden (twitter @MDbreathe) indicated that for Post- C19 Vax Sequelae (PVS) she first starts with ivermectin and sees how the patient does. Then she uses the Z-DTOX. As far as I understand it, she does not recommend high dose melatonin (over 2 mgs) nor any turmeric. Resveratrol is another ingredient that seems to block recovery/HERV-K102 particle production and should be avoided in my opinion. For the respite from the insomnia, fatigue, and extreme brain fog, I now use NuSleep (ISM Ottawa, Canada) along with whey protein, one a day vitamins, fish oil (1800 EPA and 1000 DHA) and the equivalent of Z-DTOX (except I use genistein/flavones 60 mg instead of EGCG 100 mg). In the summer I try to be outdoors for at least one hour per day to reap the benefits of Vitamin D3 and near infrared. Last year I took up pickleball.

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Dr. Marian Laderoute's avatar

This is such an important question. Allopathic medicine and natural medicine commonly use anti-inflammatories to treat chronic diseases to little or no avail. This approach never cures diseases because they are only treating the symptoms. But the cause of chronic diseases (including cancer, CVD etc) is the immunosenescence of macrophages due to the activity of alpha-fetoprotein (AFP). So to cure chronic diseases one must use DIRECT AFP ANTAGONISTS LIKE IVERMECTIN, ZINC, FLAVONES, 7-KETO-DHEA and indirect like vitamin D3 blood levels at >50 ng/ml. Many if not most anti-inflammatories are immunosuppressive and block the activation of trained (innate) immunity meaning you won't have any HERV-K102 activity to promote your survival should you become infected. However, anti-inflammatories are useful if you have cytokine storm. Interestingly, methylprednisolone (a type of corticosteroid which is anti-inflammatory) likely induces HERV-K102 expression while dexamethasone (a more powerful corticosteroid) likely blocks HERV-K102 expression and explains why more lives are spared from severe COVID-19 when methylprednisolone is used. Melatonin up to 2 mg per night is not going to inhibit trained innate immunity. Clinically we have observed that turmeric, statins and/or melatonin (>2 mg per night) worsen immunosenescence in the host and block the ability to achieve wellness. Our clinic (I am retired now from ISM) has been reversing and preventing immunosenescence in advanced cancer patients since 1998. Most herbal medicines are in fact immunosuppressive, so be careful. I hope this helps. Cannot discount the possibility for post vax sequelae that a short term exposure could help dissolve toxic spike. However, in the longer run it may be too dangerous to use immunosuppressives. Would like to see clinical trials on the use of low dose aspirin (antiinflammatory and anticlotting) to prevent clots versus breakthrough infections evaluating the risk of death. Happy New Year to you also!

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