Did the second dose of mRNA COVID-19 vaccines select for the alpha and delta variants which prolonged the pandemic?
Not the best strategy to end a pandemic. 2022 06 30
I have compiled various lines of evidence implicating the second dose of COVID-19 mRNA vaccines (which generates high levels of spike specific antibodies including neutralizing antibodies) in generating selection pressure resulting in the selection of the alpha and delta variants.
Surprisingly, little selection occurs during natural infection in the absence of vaccination (and in the absence of treatment with spike neutralizing antibodies).
Why is there little selection for immune escape variants during natural infection????
Read on to discover at least one mechanism.
It should be noted that we have no idea how the use of booster doses against the SAS-CoV-2 Wuhan strain of spike will influence the selection of omicron variants, since the latter apparently evolved in the common house mouse. Presumably, omicron variants are surfacing due to adaptation of the mouse selected strain to humans (independent of selection by vaccines) as was seen for SARS-CoV-1 (also a zoonotic transfer to humans, see Alina Chan and Matt Ridley BioRxiv, May 2, 2020). Some vaccinologists are predicting catastrophic outcomes for those who take the new omicron specific vaccines which apparently will be offered this fall without ANY safety evaluation. Some scientists are saying that while the adaptive immunity T cell response from the COVID-19 vaccines may help provide protection against hospitalization and death, or possibly the spike proteins of omicron variants do not yet have affinity for human BSG and thus, are less likely to induce cytokine storm through human BSG, another possibility is that repeated exposures to spike protein might induce "spike protein specific " T cell tolerance where a proof-of-concept provided by Andrieu JM & Lu W, published in Arch Virol May 2021 was presented as a novel paradigm for vaccine development against another enveloped pandemic RNA virus, HIV-1. It is harrowing to think that we don't know what to expect from 'omicron based spike vaccines'. Will they be deadly or will they be (somewhat) beneficial, given the US FDA has voted not to test these 'Russian Roulette' omicron vaccine 'shots' before making them available.
Looks like vaccine induced negative efficacy > ADE. The “vaccine” experiment has gone terribly wrong.